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Emendatio ex 00:04, 10 Februarii 2020

Cyclus acidi citrici vel cylcus acidorum triclyclicorum vel cyclus Krebs est iter metabolicum intracellulare et iter paenultimum in mitochondriis, ante phosphorylationem oxydativam enim, energiam cellularem (ATP) generantem.

Cyclus ex pyruvato et, non exigue, aqua generat duo substantias, electrona e^- in proximum iter portantes: NADH+H⁺ et FAD(2H).

Hic cyclus anno 1937 ab Iohanne Adolpho Krebs primo descriptus est; nimirum Krebs anno 1953 praemium Nobelianum physiologiae et medicinae addictum est^[1]. Hac de causa cyclus non raro "cyclus Krebs" apellatur. Praeterea nomen "cycli acidorum triclyclicorum" de tribus acidis tricyclicis intra cyclum Krebs (citrato, aconitato, isocitrato) partibus cursus cycli sumitur; denique nomen "cycli acidi citrici" de molecula acidi citrici, non electrice onerati, derivatur, quamquam citratum forma electrice onerata partem cycli ipsius capit.

Cursus

Aequatio generalis cycli Krebs:

Acetylo-CoA + 3 NAD⁺ + FAD + GDP + P_i+ 2 H₂O → CoA + 3 NADH + 3 H⁺ + FAD(2H) + GTP + 2 CO₂

Nota cycli Krebs ope, nec oxygenium consumatur, nec ATP generatur, sed generantur GTP et CO₂. Oxygenium quidem, ut ATP, demum in itinere proximo, phosphorylatione oxydativa, momenta maxima habebit.

Condiciones

Substrata pyruvatum generantia
Aqua (cyclo 2 moleculae)
Mitochondria sana

Gradus cycli acidi citrici

Reactio biochemica 0/10 (Citrati synthasis): Oxaloacetatum + Acetylo-CoA + H₂O → Citratum + CoA-SH
Reactio biochemica 1 (Aconitasis): Citratum + CoA-SH → cis-Aconitatum + H₂O
Reactio biochemica 2 (Aconitasis): cis-Aconitatum + H₂O → Isocitratum
Reactio biochemica 3 (Isocitrati dehydrogenasis): Isocitratum + NAD⁺ → Oxalosuccinatum + NADH + H⁺
Reactio biochemica 4 (Isocitrati dehydrogenasis): Oxalosuccinatum → α-Ketoglutaratum + CO₂
Reactio biochemica 5 (α-Ketoglutarate dehydrogenasis): α-Ketoglutaratum + NAD⁺ + CoA-SH → Succinylo-CoA + NADH + H⁺ + CO₂
Reactio biochemica 6 (Succinylo-CoA synthetasis): Succinylo-CoA + GDP + P_i → Succinatum + CoA-SH + GTP
Reactio biochemica 7 (Succinati dehydrogenasis): Succinatum + Ubiquinonum (Q) → Fumaratum + Ubiquilonum (QH₂)
Reactio biochemica 8 (Fumarasis): Fumaratum + H₂O → L-Malatum
Reactio biochemica 9 (Malati dehydrogenasis) L-Malatum + NAD⁺ → Oxaloacetatum + NADH + H⁺
Reactio biochemica 10/0 (Citrati synthasis): Oxaloacetatum + Acetylo-CoA + H₂O → Citratum + CoA-SH

Eventus

Electrona (cyclo 3 moleculae NADH+H⁺, 1 molecula FAD(2H))
GTP (cyclo 1 molecula)
CO₂ (cyclo 2 moleculae, aeris exspirati)

Notae

↑ De Iohanne Adolpho Krebs in situ praemio Nobeliano medicinae dicato (Anglice)

Nexus interni

Nexus externi

Khan academy de cycli acidi citrici. (Anglice)
Alii cursus cycli Krebs. (Anglice)

Haec stipula ad biologiam spectat. Amplifica, si potes!

[1] De Iohanne Adolpho Krebs in situ praemio Nobeliano medicinae dicato (Anglice)

[1]

@@ Linea 1: / Linea 1: @@
-[[Fasciculus:Citric acid cycle with aconitate 2 la.svg|thumb|400px|Cursus cycli acidi citrici.]]
+[[Fasciculus:Citric acid cycle with aconitate 2 la.svg|thumb|400px|'''Cursus cycli acidi citrici''']]
-'''Cyclus acidi citrici''' vel '''cylcus acidorum triclyclicorum''' vel '''cyclus Krebs''' est [[iter metabolicum]] intracellulare et iter ''paen''ultimum in [[mitochondrium|mitochondriis]], ante [[phosphorylatio oxidativa|phosphorylationem oxydativam]] enim, energiam cellularem ([[ATP]]) generandi.
+'''Cyclus acidi citrici''' vel '''cylcus acidorum triclyclicorum''' vel '''cyclus Krebs''' est [[iter metabolicum]] intracellulare et iter ''paen''ultimum in [[mitochondrium|mitochondriis]], ante [[phosphorylatio oxidativa|phosphorylationem oxydativam]] enim, energiam cellularem ([[ATP]]) generantem.
 Cyclus ex [[pyruvatum|pyruvato]] et, non exigue, [[aqua]] generat duo substantias, electrona ''e<sup>-</sup>'' in proximum iter portantes: [[Nicotinamidum adeninum dinucleotidum|NADH]]+H<sup>+</sup> et FAD(2H).
-Cyclus hic anno [[1937]] ab [[Hans Adolphus Krebs|Hans Adolphum Krebs]] primo descriptus est; nimirum Krebs anno 1953 [[Praemium Nobelianum physiologiae et medicinae]] addictum est<ref>[http://nobelprize.org/nobel_prizes/medicine/laureates/1953/index.html De Hans Adolpho Krebs] in situ Praemio Nobeliano Medicinae dicato {{Ling|Anglice}}</ref>. Hac de causa cyclus non raro "cyclus Krebs" dicitur. Praeterea, nomen "cycli acidorum triclyclicorum" de tribus acidis tricyclicis intra cyclum Krebs (citratum, aconitatum, isocitratum) partibus cursus cycli; Denique, nomen "cycli acidi citrici" de [[molecula]] [[acidum citricum|acidi citrici]], non electrice onerati, derivatur, quamquam ''citratum'' forma [[ion|electrice onerata]] partem cycli ipsius capit.
+Hic cyclus anno [[1937]] ab [[Iohannes Adolphus Krebs|Iohanne Adolpho Krebs]] primo descriptus est; nimirum Krebs anno 1953 [[praemium Nobelianum physiologiae et medicinae]] addictum est<ref>[http://nobelprize.org/nobel_prizes/medicine/laureates/1953/index.html De Iohanne Adolpho Krebs] in situ praemio Nobeliano medicinae dicato {{Ling|Anglice}}</ref>. Hac de causa cyclus non raro "cyclus Krebs" apellatur. Praeterea nomen "cycli acidorum triclyclicorum" de tribus acidis tricyclicis intra cyclum Krebs (citrato, aconitato, isocitrato) partibus cursus cycli sumitur; denique nomen "cycli acidi citrici" de [[molecula]] [[acidum citricum|acidi citrici]], non electrice onerati, derivatur, quamquam ''citratum'' forma [[ion|electrice onerata]] partem cycli ipsius capit.
 == Cursus ==
 Aequatio generalis cycli Krebs:
 :'''Acetylo-CoA + 3 NAD<sup>+</sup> + FAD + GDP + P<sub>i</sub>+ 2 H<sub>2</sub>O → CoA + 3 NADH + 3 H<sup>+</sup> + FAD(2H) + GTP + 2 CO<sub>2</sub>'''
-Nota cycli Krebs ope, <u>ne</u> [[oxygenium]] consumatur, <u>ne</u> [[ATP]] generetur, sed generentur GTP et CO<sub>2</sub>. Oxygenium quidem, ut ATP, demum in itinere proximo, [[phosphorylatio oxidativa|phosphorylatione oxydativa]], momenta maxima habebunt.
+Nota cycli Krebs ope, <u>nec</u> [[oxygenium]] consumatur, <u>nec</u> [[ATP]] generatur, sed generantur GTP et CO<sub>2</sub>. Oxygenium quidem, ut ATP, demum in itinere proximo, [[phosphorylatio oxidativa|phosphorylatione oxydativa]], momenta maxima habebit.
 === Condiciones ===