CYP2C9

E Vicipaedia
Jump to navigation Jump to search
Esculaap4.svg
Cave: notitiae huius paginae nec praescriptiones nec consilia medica sunt.


Cytochroma P450 CYP2C9.

Cytochroma P450 CYP2C9 (-atis, n.) (Numerus EC: 1.14.13.48) est haemoproteinum et pars gregis cytochromatum P450.

Natura structuraque biochemica[recensere | fontem recensere]

Cytochroma P450 CYP2C9 est et polypeptidum et haemoproteinum, quod ex 490 acidis aminicis (massa 55.628 Da) constitutum est. Intra cellulam enzymum hoc in ancoris membranae stat[1].

Genetica[recensere | fontem recensere]

Nomen geni cytochromatis est CYP2C9 locus cuius geneticus in chromosomate 10 humano locatus est (10q23.33).

Pharmaca ad CYP2C9 relata[recensere | fontem recensere]

Pharmaca relata ad CYP2C9[2][3].
Substrati Inhibitores[4] Inductores[5]
  • Rifampicinum (forte)
  • Secobarbitalum (forte)
  • Phenobarbitalum

Notae[recensere | fontem recensere]

  1. Cojocaru V, Balali-Mood K, Sansom MS, Wade RC (2011). "Structure and dynamics of the membrane-bound cytochrome P450 2C9". PLoS Comput Biol 7 (8): e1002152 
  2. Cozza KL, Armstrong SC (2001). The Cytochrome P450 System. Drug Interaction Principles for Medical Practice. Washington, DC: American Psychiatric Publishing
  3. Preskorn SH (1996). Clinical Pharmacology of Selective Serotonin Reuptake Inhibitors. 1st ed.: Professional Communications, Inc.
  4. Inhibitor cum subtratorum effectibus fortioribus
  5. Inductor cum subtratorum effectibus minoribus
  6. Berka K, Hendrychová T, Anzenbacher P, Otyepka M (2011). "Membrane position of ibuprofen agrees with suggested access path entrance to cytochrome P450 2C9 active site". J Phys Chem A 115 (41): 11248-55 

Nexus externi[recensere | fontem recensere]