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Emendatio ex 18:23, 1 Ianuarii 2020

Cyclus acidi citrici vel cylcus acidorum triclyclicorum vel cyclus Krebs est iter metabolicum intracellulare et iter paenultimum in mitochondriis, ante phosphorylationem oxydativam enim, energiam cellularem (ATP) generandi.

Cyclus ex pyruvato et, non exigue, aqua generat duo substantias, electrona e^- in proximum iter portantes: NADH+H⁺ et FAD(2H).

Cyclus hic anno 1937 ab Hans Adolphum Krebs primo descriptus est; nimirum Krebs anno 1953 Praemium Nobelianum physiologiae et medicinae addictum est^[1]. Hac de causa cyclus non raro "cyclus Krebs" dicitur. Praeterea, nomen "cycli acidorum triclyclicorum" de tribus acidis tricyclicis intra cyclum Krebs (citratum, aconitatum, isocitratum) partibus cursus cycli; Denique, nomen "cycli acidi citrici" de molecula acidi citrici, non electrice onerati, derivatur, quamquam citratum forma electrice onerata partem cycli ipsius capit.

Cursus

Condiciones

Substrata pyruvatum generantia
Aqua (cyclo 2 moleculae)
Mitochondria sana

Gradus cycli acidi citrici

Reactio biochemica 0/10 (Citrati synthasis): Oxaloacetatum + Acetylo-CoA + H₂O → Citratum + CoA-SH
Reactio biochemica 1 (Aconitasis): Citratum + CoA-SH → cis-Aconitatum + H₂O
Reactio biochemica 2 (Aconitasis): cis-Aconitatum + H₂O → Isocitratum
Reactio biochemica 3 (Isocitrati dehydrogenasis): Isocitratum + NAD⁺ → Oxalosuccinatum + NADH + H⁺
Reactio biochemica 4 (Isocitrati dehydrogenasis): Oxalosuccinatum → α-Ketoglutaratum + CO₂
Reactio biochemica 5 (α-Ketoglutarate dehydrogenasis): α-Ketoglutaratum + NAD⁺ + CoA-SH → Succinylo-CoA + NADH + H⁺ + CO₂
Reactio biochemica 6 (Succinylo-CoA synthetasis): Succinylo-CoA + GDP + P_i → Succinatum + CoA-SH + GTP
Reactio biochemica 7 (Succinati dehydrogenasis): Succinatum + Ubiquinonum (Q) → Fumaratum + Ubiquilonum (QH₂)
Reactio biochemica 8 (Fumarasis): Fumaratum + H₂O → L-Malatum
Reactio biochemica 9 (Malati dehydrogenasis) L-Malatum + NAD⁺ → Oxaloacetatum + NADH + H⁺
Reactio biochemica 10/0 (Citrati synthasis): Oxaloacetatum + Acetylo-CoA + H₂O → Citratum + CoA-SH

Eventus

Electrona (cyclo 3 moleculae NADH+H⁺, 1 molecula FAD(2H))
GTP (cyclo 1 molecula)
CO₂ (cyclo 2 moleculae, aeris exspirati)

Notae

↑ De Hans Adolpho Krebs in situ Praemio Nobeliano Medicinae dicato (Anglice)

Nexus interni

Nexus externi

Khan academy de cycli acidi citrici. (Anglice)
Alii cursus cycli Krebs. (Anglice)

Haec stipula ad biologiam spectat. Amplifica, si potes!

[1] De Hans Adolpho Krebs in situ Praemio Nobeliano Medicinae dicato (Anglice)

[1]

@@ Linea 4: / Linea 4: @@
 Cyclus ex [[pyruvatum|pyruvato]] et, non exigue, [[aqua]] generat duo substantias, electrona ''e<sup>-</sup>'' in proximum iter portantes: [[Nicotinamidum adeninum dinucleotidum|NADH]]+H<sup>+</sup> et FAD(2H).
-Cyclus hic anno [[1937]] ab [[Hans Adolphus Krebs|Hans Adolphum Krebs]] primo descriptus est; nimirum Krebs anno 1953 [[Praemium Nobelianum physiologiae et medicinae]] addictum est<ref>[http://nobelprize.org/nobel_prizes/medicine/laureates/1953/index.html De Hans Adolpho Krebs] in situ Praemio Nobeliano Medicinae dicato {{Ling|Anglice}}</ref>. Hac de causa cyclus non raro "cyclus Krebs" dicitur. Praeterea, nomen "cycli acidorum triclyclicorum" de tribus acidis tricyclicis intra cyclum Krebs (citratum, isocitratum, aconitatum) partibus cursus cycli; Denique, nomen "cycli acidi citrici" de [[molecula]] [[acidum citricum|acidi citrici]], non electrice onerati, derivatur, quamquam ''citratum'' forma [[ion|electrice onerata]] partem cycli ipsius capit.
+Cyclus hic anno [[1937]] ab [[Hans Adolphus Krebs|Hans Adolphum Krebs]] primo descriptus est; nimirum Krebs anno 1953 [[Praemium Nobelianum physiologiae et medicinae]] addictum est<ref>[http://nobelprize.org/nobel_prizes/medicine/laureates/1953/index.html De Hans Adolpho Krebs] in situ Praemio Nobeliano Medicinae dicato {{Ling|Anglice}}</ref>. Hac de causa cyclus non raro "cyclus Krebs" dicitur. Praeterea, nomen "cycli acidorum triclyclicorum" de tribus acidis tricyclicis intra cyclum Krebs (citratum, aconitatum, isocitratum) partibus cursus cycli; Denique, nomen "cycli acidi citrici" de [[molecula]] [[acidum citricum|acidi citrici]], non electrice onerati, derivatur, quamquam ''citratum'' forma [[ion|electrice onerata]] partem cycli ipsius capit.
+== Cursus ==
 === Condiciones ===
 * Substrata [[pyruvatum]] generantia
-* [[Aqua]]
+* [[Aqua]] (cyclo 2 moleculae)
 * [[Mitochondrium|Mitochondria]] sana
+=== Gradus cycli acidi citrici ===
+* Reactio biochemica 0/10 (Citrati synthasis): Oxaloacetatum + Acetylo-CoA + [[Aqua|H<sub>2</sub>O]] → Citratum + CoA-SH
+* Reactio biochemica 1 (Aconitasis): Citratum + CoA-SH → ''cis''-Aconitatum + H<sub>2</sub>O
+* Reactio biochemica 2 (Aconitasis): ''cis''-Aconitatum + [[Aqua|H<sub>2</sub>O]] → Isocitratum
+* Reactio biochemica 3 (Isocitrati dehydrogenasis): Isocitratum + NAD<sup>+</sup> → Oxalosuccinatum + NADH + H<sup>+</sup>
+* Reactio biochemica 4 (Isocitrati dehydrogenasis): Oxalosuccinatum → α-Ketoglutaratum + CO<sub>2</sub>
+* Reactio biochemica 5 (α-Ketoglutarate dehydrogenasis): α-Ketoglutaratum + NAD<sup>+</sup> + CoA-SH → Succinylo-CoA + NADH + H<sup>+</sup> + CO<sub>2</sub>
+* Reactio biochemica 6 (Succinylo-CoA synthetasis): Succinylo-CoA + [[GDP]] + [[Phosphatum|P<sub>i</sub>]] → Succinatum + CoA-SH + [[GTP]]
+* Reactio biochemica 7 (Succinati dehydrogenasis): Succinatum + [[Coenzymum Q10|Ubiquinonum (Q)]] → Fumaratum + Ubiquilonum (QH<sub>2</sub>)
+* Reactio biochemica 8 (Fumarasis): Fumaratum + [[Aqua|H<sub>2</sub>O]] → <small>L</small>-Malatum
+* Reactio biochemica 9 (Malati dehydrogenasis) <small>L</small>-Malatum + NAD<sup>+</sup> → Oxaloacetatum + NADH + H<sup>+</sup>
+* Reactio biochemica 10/0 (Citrati synthasis): Oxaloacetatum + Acetylo-CoA + H<sub>2</sub>O → Citratum + CoA-SH
 === Eventus ===
-* [[Electron]]a (3 moleculae NADH+H<sup>+</sup>, 1 molecula FAD(2H))
+* [[Electron]]a (cyclo 3 moleculae NADH+H<sup>+</sup>, 1 molecula FAD(2H))
-* GTP
+* GTP (cyclo 1 molecula)
+* CO<sub>2</sub> (cyclo 2 moleculae, aeris exspirati)
 == Notae ==