Receptorium neurotransmissoris
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Receptorium neurotransmissoris est receptorium cellulare membranorum neuroni locatum ac commotum substantiis aptiis enimvero non solum neurotransmissoribus, sed etiam medicamentis et moleculiis signum dantibus aliis, ut signa chemica per membranam in neuronem perveniant id ea imprimis canales iontici patefieri claudive possint.
Typi receptoriorum
[recensere | fontem recensere]Duo typi receptoriorum sunt:
- Receptoria ligando saepta sive receptoria ionotropica[1] - receptorium neurotransmissore (ligando) et excitatum, per exemplum glutamato vel aspartato, et inhibitum, per exemplum GABA sive glycino.
- Receptoria proteino G copulata sive receptoria metabotropica[2] - receptoriis nulla functio directa neque excitans neque inhibens habent, sed functio indirecta neurotransmissorum effectus modificans. Plurimi receptoriorum metabotropici sunt.
Receptoriorum exempla
[recensere | fontem recensere]Exempla receptoriorum neurotransmissorium sunt:[3]
- Receptoria adrenergica: alpha (α): α1A, α1B, α1D[4], α2A, α2B, α2C, α2D; beta (β): β1, β2, β3
- Receptoria dopamini: D1, D2, r3, D4, D5
- Receptoria GABA: GABAA, GABAA-ρ, GABAB1a, GABAB1δ, GABAB2
- Receptoria glutamati: NMDA, AMPA, kainati, mGluR1, mGluR2, mGluR3, mGluR4, mGluR5, mGluR6, mGluR7, mGluR8
- Receptoria histamini: H1, H2, H3, H4
- Receptoria acetylcholini: muscarinica: M1, M2, M3, M4, M5; nicotinica: musculi, nervi (α-bungarotoxini-insensibile), nervi (α-bungarotoxini-sensibile)
- Receptoria opioidorum[5]: μ, δ1, δ2, κ
- Receptoria serotonini[6]: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT1F, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT4, 5-HT5A, 5-HT5B, 5-HT6, 5-HT7
- Receptorium glycini: glycinum
Notae
[recensere | fontem recensere]- ↑ Anglice: Ligand-gated receptor, ionotropic receptor
- ↑ Anglice: G Protein-coupled receptor, metabotropic receptor
- ↑ ed. Kebabain, J. W. & Neumeyer, J. L. (1994). "RBI Handbook of Receptor Classification"
- ↑ receptorium adrenergicum α1C non est; explanationis vide → receptorium adrenergicum alpha-1.
- ↑ http://themedicalbiochemistrypage.org/opioids.php#receptors
- ↑ HT = Hydroxytryptaminum, 5-Hydroxytryptaminum = Serotoninum
Nexus interni
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