Receptorium glutamati

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Acidum glutamicum

Receptorium glutamati est receptorium neurotransmissoris synapsium neuroni locatum atque acido glutamico (glutamato)[1] neurotransmissore excitatorio cerebri primo stimulatum[2]. Haec receptoria in receptoria ionotropica, ipsa canalibus cationium servantia, et metabotropica, cum proteino G alteras canales modificantia, dividuntur. Receptoriorum ionotropicorum glutamati tres familiae notae sunt: receptoria AMPA, receptoria kainati, receptoria NMDA. Receptoria glutamati metabotropica quoque in tres greges (I-II-III) dividuntur.

In stimulando glutamato aliisque stimulis aptis neuroni receptoria Glutamati portantes, quibus grave pondus communicationis inter neuronos et formationis memoriae et eventuum discendi et ordinationis habet, neuronos postsynapticos excitant.?

Et partes excitotoxicitatis centrales receptoriorum glutamati et praevalentia ipsorum in systemate nervoso centrali cum morbis neurodegenerativis attribuuntur, nihilo setius autem attribuere suspiciuntur. Autoanticorpora contra receptoria eadem pluribus morbis coniuncta sunt veluti singulae formae morbi comitialis, Lupi erythematodis, ictuum.

Species[recensere | fontem recensere]

Species Nomen Agonistis[3]
ionotropicae Receptoria NMDA NMDA
Receptoria Kainati Kainatum
Receptoria AMPA AMPA
metabotropicae mGluR L-AP4, ACPD, L-QA[4]

Ionotropicae[recensere | fontem recensere]

Subunitates Receptoriorum ionotropicorum glutamati cum genis suis:[5][6]

Familia receptoriorum Subunitas

(nomenclatura prior)

Genum Chromosoma
(humanum)
AMPA GluA1 (GluR1) GRIA1 5q33
GluA2 (GluR2) GRIA2 4q32-33
GluA3 (GluR3) GRIA3 Xq25-26
GluA4 (GluR4) GRIA4 11q22-23
Kainatum GluK1 (GluR5) GRIK1 21q21.1-22.1
GluK2 (GluR6) GRIK2 6q16.3-q21
GluK3 (GluR7) GRIK3 1p34-33
GluK4 (KA-1) GRIK4 11q22.3
GluK5 (KA-2) GRIK5 19q13.2
NMDA GluN1(NR1) GRIN1 9q34.3
GluN2A (NR2A) GRIN2A 16p13.2
GluN2B (NR2B) GRIN2B 12p12
GluN2C (NR2C) GRIN2C 17q24-25
GluN2D (NR2D) GRIN2D 19q13.1qter
GluN3A (NR3A) GRIN3A 9q31.1
GluN3B (NR3B) GRIN3B 19p13.3

Metabotropicae[recensere | fontem recensere]

Mammalium receptoria metabotropica glutamati mGluR# nominantur, tres greges sunt:

Grex Receptorium Genum Chromosoma
(humanum)
Effectus
1 mGluR1 GRM1 6q24 Incrementum Ca2+ in cytoplasmate.
mGluR5 GRM5 11q14.3 Liberatio K+ ex cellula canalibus ionticis K+
2 mGluR2 GRM2 3p21.2 Inhibitio adenylyl cyclasis, decrementum cAMP
mGluR3 GRM3 7q21.1-q21.2
3 mGluR4 GRM4 6p21.3 Incrementum canalum ionticorum Ca2+, cum influxu Ca2+ intra cellulam[7]
mGluR6 GRM6 5q35
mGluR7 GRM7 3p26-p25
mGluR8 GRM8 7q31.3-q32.1

Notae[recensere | fontem recensere]

  1. Basis coniugata acidi glutamici.
  2. http://www.bristol.ac.uk/synaptic/receptors/ Receptoria Glutamati, Universitas Bristolii] (Anglice)
  3. Agonistis = αγωνιστής (Graece)
  4. Ohashi H, Maruyama T, Higashi-Matsumoto H, Nomoto T, Nishimura S, Takeuchi (2002). A novel binding assay for metabotropic glutamate receptors using [3H] L-quisqualic acid and recombinant receptors. Z Naturforsch [C] 57 (3–4): 348–55
  5. Dingledine R, Borges K, Bowie D, Traynelis SF (March 1999). "The glutamate receptor ion channels". Pharmacol. Rev. 51 (1): 7–61 
  6. Andersson O, Stenqvist A, Attersand A, von Euler G (December 2001). "Nucleotide sequence, genomic organization, and chromosomal localization of genes encoding the human NMDA receptor subunits NR3A and NR3B". Genomics 78 (3): 178–84 
  7. "Metabotropic glutamate receptors in the basal ganglia motor circuit". Nature Reviews Neuroscience 6 (10): 787–98. 2005 

Nexus interni