Receptorium serotonini
Receptoria Serotonini sive receptoria 5-HT sunt systematis nervosi classis receptoriorum proteino G copulatorum (cum serotonino ligando endogeno) et canalium ionticarum ligando reclusarum.
Classificatio
[recensere | fontem recensere]Expers receptorium 5-HT3, quod canalis ionticus ligando reclusa, receptoria seroniti sunt receptoria cum Proteino G copulata quae excitantis effectus inhibentisve intra cellula alteri legati seriem perficit. Anno 2014 novum receptorium serotonini pieris rapae, vocatur pr5-HT8, descriptum est.[1]
Familiae
[recensere | fontem recensere]Plerisque receptoriis serotonini effectus excitantes, sed nonnullis (5-HT1 et 5-HT5) inhibentes sunt.
| Familia | Typus | Scopus | Effectus |
| 5-HT1: 5-HT1A, 5-HT1B, 5-HT1D[2], 5-HT1E, 5-HT1F | Gi/Go-proteino copulatum. | cAMP ↓ | inhibens |
| 5-HT2: 5-HT2A, 5-HT2B, 5-HT2C | Gq/Gq/11-proteino copulatum. | IP3 ↑, DAG ↑ | excitans |
| 5-HT3 | canalis ionticus ligando reclusa Na+ et K+. | membranam plasmaticam | excitans |
| 5-HT4 | Gs-proteino copulatum. | cAMP ↑ | excitans |
| 5-HT5[3] | Gi/Go-proteino copulatum.[4] | cAMP ↓ | inhibens |
| 5-HT6 | Gs-proteino copulatum. | cAMP ↑ | excitans |
| 5-HT7 | Gs-proteino copulatum. | cAMP ↑ | excitans |
Notae
[recensere | fontem recensere]- ↑ "Larvae of the small white butterfly, Pieris rapae, express a novel serotonin receptor". J. Neurochem. 131: 767–77. 2014
- ↑ Receptorium 5-HT1Cnon est.
- ↑ Subtypi 5A et 5B investigati sunt, in hominibus autem solum subtypus 5A exprimitur.
- ↑ "The human 5-ht5A receptor couples to Gi/Go proteins and inhibits adenylate cyclase in HEK 293 cells". Eur J Pharmacol. 361 (2–3): 299–309. 1998
Plura legere si cupis
[recensere | fontem recensere]- Daniel Wacker et alii, "Crystal Structure of an LSD-Bound Human Serotonin Receptor", Cell, 2017: 377-389.