Transportator neurotransmissoris

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Transportator neurotransmissoris sunt proteinorum genera proteinorum transportatorum membranaceorum membranas neuronorum transeuntes, familiae portatorum solubilium 6 (SLC6)[1]. Munera eorum principalia neurotransmissores trans membranas cellulares vehi constant.

Distinguuntur transportatores vesicales, qui neurotransmissores in vesiculas movent, ideo magnitudinem eorum intra vesiculas gubernantes[2]. Transportatores vesicales gradienti electrochemico pendunt, hydrolysi causa et ope consumptionis ATP agente. Adhibitio gradientium electrochemicorum vero pleorumque transportatorum neurotransmissoris haud insolita videtur.

De consuetudine omnes transportatorum a fissura synaptica reabsorptionem in bulbulum terminalem perficiunt. Quibusdam in cellulis vero in contrarium vertantur: tunc neurotransmissores per emissionem non vesicularem ex bulbulo synaptico liberantur.

Hodie diversa medicamenta (per exemplum antidepressiva, psychostimulantes, anticonvulsivum Tiagabinum[3]) effectus suos loco transportatorum exercent. Et videbatur, ut transportatores utiles inventionis medicamentorum novorum possint[4].

Genera transportatorum neurotransmissoris[recensere | fontem recensere]

Structura synapsis chemicae

Adhuc incogniti sunt transportatores et histamini et endocannabinoidorum.

Notae[recensere | fontem recensere]

  1. Kristensen A. S., Andersen J. (Sep 2011). "SLC6 Neurotransmitter Transporters: Structure, Function, and Regulation". Pharmacological Reviews 63 (3): 585-640 
  2. Anne C., Gasnier B. (2014). "Vesicular Neurotransmitter Transporters: Mechanistic Aspects". Current topics in membranes 73: 149-74 
  3. Sałat K., Podkowa A, et al. (Iun 2015). "Anticonvulsant Active Inhibitor of GABA Transporter Subtype 1, Tiagabine, With Activity in Mouse Models of Anxiety, Pain and Depression". Pharmacological reports 67 (3): 465-72 
  4. Iversen L. (Iul 2000). "Neurotransmitter Transporters: Fruitful Targets for CNS Drug Discovery". Molecular Psychiatry 5 (4): 357-62 

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