CYP2B6

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Cytochroma P450 CYP2B6 (-atis, n.) (Numerus EC: 1.14.14.1) est enzymum et haemoproteinum et pars gregis Cytochroma P450 ideo in metabolismo medicamenti chemotherapiae, ut cyclophosphamidi sive ifosfamidi, interest. Circiter centesimae quinque reactionum catabolicarum medicamentorum cum cytochromate CYP2B6 patent[1]. Variationes multae geneticae descriptae sunt.

Genetica[recensere | fontem recensere]

Phaenotypicae variantia[recensere | fontem recensere]

Locus geni geneticus CYP2B6 in chromosomate 19 (19q13.2) situs est[2]. Polymorphismus geneticus cum plus quam centum variationibus magnum momentum habet[1]

Pharmaca ad CYP2B6 relata[recensere | fontem recensere]

Pharmaca relata ad CYP2B6[3][4].
Substrati Inhibitores[5] Inductores[6]

Nexus interni


Notae[recensere | fontem recensere]

  1. 1.0 1.1 Turpeinen M, Zanger UM (2012). "Cytochrome P450 2B6: function, genetics, and clinical relevance". Drug Metabol Drug Interact 27 (4): 185-97 
  2. "Entrez geni: cytochromum P450 CYP2B6" 
  3. Cozza KL, Armstrong SC (2001). The Cytochrome P450 System. Drug Interaction Principles for Medical Practice. Washington, DC: American Psychiatric Publishing
  4. Preskorn SH (1996). Clinical Pharmacology of Selective Serotonin Reuptake Inhibitors. 1st ed.: Professional Communications, Inc.
  5. Inhibitor cum subtratorum effectibus fortioribus
  6. Inductor cum subtratorum effectibus minoribus
  7. Andrade C (2017). "Ketamine for Depression, 5: Potential Pharmacokinetic and Pharmacodynamic Drug Interactions". J Clin Psychiatry 78 (7): e858-61 
  8. Kharasch ED, Stubbert K (2013). "Role of cytochrome P4502B6 in methadone metabolism and clearance". J Clin Pharmacol 53 (3): 305-13 

Nexus externi[recensere | fontem recensere]