Tamoxifenum
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| Natura chemica | |
|---|---|
| Formula chemica | C26H29NO |
| Massa molaris | 371.515 g/mol |
| PubChem | 2733526 |
| DrugBank | DB00675 |
| Natura pharmacologica | |
| Codex ATC | L02BA01 (WHO) |
| Tempus semivitae biologicum | 5-7 dies |
| Metabolismus | iecore (hepaticus) |
| Metabolitus | Afimoxifenum, Endoxifenum |
| Substratum enzymi | CYP2C9 CYP2D6 CYP3A4 |
| Excretio | faecibus 65%, renibus 9% |
| Ad usum therapeuticum | |
| Applicatio | per os |
| MedlinePlus | a682414 (Anglice) |
Tamoxifenum est prodroga, at metaboliti activi eius, Afimoxifenum et Endoxifenum potissime receptoriis oestrogenii adiungunt. Usus est therapia et complementum cancri mammae[1].
Tamoxifenum in ordinis mundi sanitarii indicem exemplarem medicamentorum essentialium receptum est.
Natura Tamoxifeni[recensere | fontem recensere]
Natura chemica[recensere | fontem recensere]
Nomen IUPAC suum est (Z)-2-[4-(1,2-diphenylbut-1-enyl)phenoxy]-N,N-dimethyl-aethylaminum. Formula chemica summa Ciprofloxacini est C26H29NO , massa molaris sua 371.515 g/mol.
Natura pharmacologica[recensere | fontem recensere]
Tamoxifenum est aromatasis inhibitor. Substantia in codice ATC reperitur: L02BA01 (WHO).
Effectus Tamoxifeni[recensere | fontem recensere]
Effectus non grati[recensere | fontem recensere]
Cum Tamoxifeni consumptione effectus secundarios et interactiones observati sunt, per exemplo:
- in cerebro: cognitionis impedimentum[2]
- in oculis: oedema maculae, opacidades corneales, retinopathiae, cataracta
- in corde: intervallum QT prolongatum
- in iecore: transaminasum augmen
Nexus interni
Notae[recensere | fontem recensere]
- ↑ Criscitiello C, Fumagalli D, Saini KS, Loi S (2010). "Tamoxifen in early-stage estrogen receptor-positive breast cancer: overview of clinical use and molecular biomarkers for patient selection". Onco Targets Ther 4: 1-11
- ↑ Paganini-Hill A, Clark LJ (2000). "Preliminary assessment of cognitive function in breast cancer patients treated with tamoxifen". Breast Cancer Res Treat 64 (2): 165-76
Nexus externi[recensere | fontem recensere]
- Drugs.com: de Tamoxifeno. (Anglice)