Doxepinum

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Doxepinum
Cognitores
ChemSpider 3046
PubChem 3158
DrugBank DB01142
Natura chemica
Doxepinum
Doxepinum
Formula chemica C
19
H
21
NO
Massa molaris 279.376 g/mol
Natura pharmacologica
Codex ATC N06AA12 (WHO)
Tempus semivitae biologicum 17 (8-24) h
Nor-Doxepinum: 31 h
Metabolismus Iecore (hepaticus):
CYP2D6
CYP2C19
Metabolitus Nor-Doxepinum
Excretio renibus (ca. 50%),
faecibus: minus
Ad usum therapeuticum
Applicatio per os, i.v., i.m.
MedlinePlus a682390 (Anglice)

Doxepinum est substantia psychoanaleptica et antidepressiva, ergo medicamentum tractationis depressionum, praesertim cum insomnia praesente, effectu sedativo suo causa, quia Doxepinum receptorium H1 agonista inversa[1] obsidet. Per structuram chemicam Doxepinum est antidepressivum tricyclicum. Ceroma[2] quoque Doxepinum therapiae pruritus[3] et dermatitis atopicae et lichenis simplicis chronici (neurodermatitis) brevis temporis adhiberi potest.

Natura Doxepini[recensere | fontem recensere]

Natura chemica[recensere | fontem recensere]

Formula summarum est C
19
H
21
NO
. Nomen IUPAC est 3-(dibenzo[b,e]oxepino-11(6H)-ylideno)-N,N-dimethylo-propano-1-aminum.

Massa molaris est 279.376 g/mol.

Nexus interni

Notae[recensere | fontem recensere]

  1. Shiroishi M, Kobayashi T (2017). "Structural Analysis of the Histamine H1 Receptor". Handb Exp Pharmacol 241: 21-30 
  2. Leppert W, Malec-Milewska M, Zajaczkowska R, Wordliczek J (2018). "Transdermal and Topical Drug Administration in the Treatment of Pain". Molecules 23 (3): pii:E681 
  3. Kaur R, Sinha VR (2018). "Antidepressants as antipruritic agents: A review". Eur Neuropsychopharmacol 28 (3): 341-52