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[[Fasciculus:Inflammasome vector.svg|thumb|Structura inflammasomatis NLRP3.]]
[[Fasciculus:Inflammasome vector.svg|thumb|Structura inflammasomatis NLRP3.]]
'''Inflammasoma''' {{victio|soma|atis|n}} est complexus [[proteinum|proteinorum]] [[oligomerus (chemia)| oligomerus]] [[inflammatio|inflammatoria responsa]]<ref name="TSCHOPP02">{{cite journal |authors=Martinon F., Burns K., Tschopp J. |title=The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta |journal=Mol Cell |year=2002 |volume=10 |issue=2 |pages=417-26 |url=https://www.ncbi.nlm.nih.gov/pubmed/12191486}}</ref> per varios ''adaptores''<ref>{{cite journal |authors=Mariathasan S., Newton K., Monack D. M., Vucic D., French D. M., Lee W. P., Roose-Girma M., Erickson S., Dixit V. M. |title=Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf |journal=Nature |year=2004 |volume=430 |issue=6996 |pages=213-8 |url=https://www.ncbi.nlm.nih.gov/pubmed/15190255}}</ref> excitatu. Adaptoribus incitatum his inflammasoma [[enzymum]] [[caspasis 1|caspasem 1]]<ref>seu ''interleukini 1 beta convertasis''</ref> se immutare impellit ita, ut praecursor [[interleukinum 1 beta|interleukini 1 beta]] [[macrophagocytis]] liberatus in formam activam interleukinumi 1 activi (IL-1β) et [[febris|febrem]] generantis convertatur ideoque cataracta inflammationis biochemica continuetur.
'''Inflammasoma''' {{victio|soma|atis|n}} est complexus [[proteinum|proteinorum]] [[oligomerus (chemia)|oligomerorum]] [[inflammatio|responsa inflammatoria]]<ref name="TSCHOPP02">{{cite journal |authors=Martinon F., Burns K., Tschopp J. |title=The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta |journal=Mol Cell |year=2002 |volume=10 |issue=2 |pages=417-26 |url=https://www.ncbi.nlm.nih.gov/pubmed/12191486}}.</ref> per varios ''adaptores''<ref>{{cite journal |authors=Mariathasan S., Newton K., Monack D. M., Vucic D., French D. M., Lee W. P., Roose-Girma M., Erickson S., Dixit V. M. |title=Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf |journal=Nature |year=2004 |volume=430 |issue=6996 |pages=213-8 |url=https://www.ncbi.nlm.nih.gov/pubmed/15190255}}.</ref> excitatus. Adaptoribus incitatum his inflammasoma [[enzymum]] [[caspasis 1|caspasem 1]]<ref>seu ''interleukini 1 beta convertasis''</ref> se immutare impellit ita, ut praecursor [[interleukinum 1 beta|interleukini 1 beta]] [[macrophagocytis]] liberatus in formam activam interleukinumi 1 activi (IL-1β) et [[febris|febrem]] generantis convertatur ideoque cataracta inflammationis biochemica continuetur.


''Inflammasomata complexus'', qui in [[textus myeloideus|textu myeloideo]] locati sunt ex enzymis caspasi 1 ac ''[[PYCARD]]'' et receptorio ''[[NALP]]'' et nonnumquam enzymo [[caspasis 5|caspasi 5]] compositi sunt. Variae formae rececptoriorum ''NALP'' complexu ligatae notae sunt.
''Inflammasomata complexus'', qui in [[textus myeloideus|textu myeloideo]] locati sunt ex enzymis caspasi 1 ac ''[[PYCARD]]'' et receptorio ''[[NALP]]'' et nonnumquam enzymo [[caspasis 5|caspasi 5]] compositi sunt. Variae formae rececptoriorum ''NALP'' complexu ligatae notae sunt.
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=== Contextus ===
=== Contextus ===
Sub [[inflammatio]]nem ''[[systema immunitatis]] innatum'' machinationem defensionis contestari oportet. Post stimulationem inflammasomate primum liberatio ex cellula cytokinorum conceditur, deinde extra cellulam [[pyroptosis]] (mors cellularum programmata) fit<ref>{{cite journal |authors=Fink S. L., Cookson B. T. |title=Caspase-1-dependent pore formation during pyroptosis leads to osmotic lysis of infected host macrophages |journal=Cell Microbiol |year=2006 |volume=8 |issue=11 |pages=1812-25 |url=https://www.ncbi.nlm.nih.gov/pubmed/16824040}}</ref>.
Sub [[inflammatio]]nem ''[[systema immunitatis]] innatum'' machinationem defensionis contestari oportet. Post stimulationem inflammasomate primum liberatio ex cellula cytokinorum conceditur, deinde extra cellulam [[pyroptosis]] (mors cellularum programmata) fit<ref>{{cite journal |authors=Fink S. L., Cookson B. T. |title=Caspase-1-dependent pore formation during pyroptosis leads to osmotic lysis of infected host macrophages |journal=Cell Microbiol |year=2006 |volume=8 |issue=11 |pages=1812-25 |url=https://www.ncbi.nlm.nih.gov/pubmed/16824040}}.</ref>.


=== Structura ===
=== Structura ===
Inflammasomata sunt complexus ex diversis proteinis compositi, ita ex [[enzymum|enzymis]] [[caspasis 1|caspasi 1]] ac ''[[PYCARD]]'' et receptorio ''[[NALP]]'' et nonnumquam enzymo [[caspasis 5|caspasi 5]]. Variae formae rececptoriorum ''NALP'' complexu ligatae notae sunt, quo inflammasomata ''NLRP1'' et ''NLRP3''<ref>{{cite journal |authors=Lebeaupin C., Proics E., de Bieville C. H., Rousseau D., Bonnafous S., Patouraux S., Adam G., Lavallard V. J., Rovere C., Le Thuc O., Saint-Paul M. C., Anty R., Schneck AS., Iannelli A., Gugenheim J., Tran A., Gual P., Bailly-Maitre B. |title=ER stress induces NLRP3 inflammasome activation and hepatocyte death |journal=Cell Death Dis |year=2015 |volume=6 |issue= |pages=e1879 |url=https://www.ncbi.nlm.nih.gov/pubmed/26355342}}</ref> et ''NLRC4'' munerum singularium nominata sunt.
Inflammasomata sunt complexus ex diversis proteinis compositi, ita ex [[enzymum|enzymis]] [[caspasis 1|caspasi 1]] ac ''[[PYCARD]]'' et receptorio ''[[NALP]]'' et nonnumquam enzymo [[caspasis 5|caspasi 5]]. Variae formae rececptoriorum ''NALP'' complexu ligatae notae sunt, quo inflammasomata ''NLRP1'' et ''NLRP3''<ref>{{cite journal |authors=Lebeaupin C., Proics E., de Bieville C. H., Rousseau D., Bonnafous S., Patouraux S., Adam G., Lavallard V. J., Rovere C., Le Thuc O., Saint-Paul M. C., Anty R., Schneck AS., Iannelli A., Gugenheim J., Tran A., Gual P., Bailly-Maitre B. |title=ER stress induces NLRP3 inflammasome activation and hepatocyte death |journal=Cell Death Dis |year=2015 |volume=6 |issue= |pages=e1879 |url=https://www.ncbi.nlm.nih.gov/pubmed/26355342}.}</ref> et ''NLRC4'' munerum singularium nominata sunt.


=== Physiologia ===
=== Physiologia ===
Quando [[infectio]] prodit cellulae systematis immunitatis, ut [[monocytus|monocyti]], [[macrophagocytus|macrophagocyti]] receptoria peculiaria, ''receptoria exempla cognoscendorum'' (Anglice: ''Pattern Recognition Receptors'', ''PRR'') enim, exprimunt: et superficie membranae et intra cellulam.
Quando [[infectio]] prodit cellulae systematis immunitatis, ut [[monocytus|monocyti]], [[macrophagocytus|macrophagocyti]] receptoria peculiaria, ''receptoria exempla cognoscendorum'' (Anglice ''Pattern Recognition Receptors'', ''PRR'') enim, exprimunt: et superficie membranae et intra cellulam.


Haec ''PRR''′ia modo duo genera stimulorum cognoscunt: ''PAMP'' vel ''DAMP''. ''PAMP'' est abbreviatura Anglica "pathogenis sociatorum exemplorum molecularis" (''pathogen-associated molecular patterns''), quae sunt partes ''corpori alienae'', per exemplum lipopolysaccharidi bacteriorum. Pluribus exemplis alienis receptoria propria ex familia [[receptorium typi Toll instar|receptoriorum typi Toll instar]] (abbreviatura internationalis: ''TLR'') superficie cellulae sunt; Exemplum [[Flagellum (biologia)|flagella bacterialia]] per [[receptorium typi Toll instar 5|TLR 5]] superficie membranae cellularum immunitatis recognoscuntur<ref>{{cite journal |authors=Rumbo M., Nempont C., Kraehenbuhl J. P., Sirard J. C. |title=Mucosal interplay among commensal and pathogenic bacteria: lessons from flagellin and Toll-like receptor 5 |journal=FEBS Lett |year=2006 |volume=580 |issue=12 |pages=2976-84 |url=https://www.ncbi.nlm.nih.gov/pubmed/16650409}}</ref>. ''DAMP'' sunt "vastitatibus sociata exempla molecularia" (''damage-associated molecular patterns''), quae sunt partes cellularum vulneratarum ''corporis poprii'' denaturatae: Quando damnum cellularum prodit, organella ex cellula liberata signum initii inflammationis fient<ref>{{cite journal |authors=Rubartelli A., Lotze M. T. |title=Inside, outside, upside down: damage-associated molecular-pattern molecules (DAMPs) and redox |journal=Curr Opin Immunol |year=2007 |volume=23 |issue=5 |pages=591-7 |url=https://www.ncbi.nlm.nih.gov/pubmed/17845865}}</ref>.
Haec ''PRR''′ia modo duo genera stimulorum cognoscunt: ''PAMP'' vel ''DAMP''. ''PAMP'' est abbreviatura Anglica "pathogenis sociatorum exemplorum molecularis" (''pathogen-associated molecular patterns''), quae sunt partes ''corpori alienae'', per exemplum lipopolysaccharidi bacteriorum. Pluribus exemplis alienis receptoria propria ex familia [[receptorium typi Toll instar|receptoriorum typi Toll instar]] (abbreviatura internationalis: ''TLR'') superficie cellulae sunt; Exemplum [[Flagellum (biologia)|flagella bacterialia]] per [[receptorium typi Toll instar 5|TLR 5]] superficie membranae cellularum immunitatis recognoscuntur<ref>{{cite journal |authors=Rumbo M., Nempont C., Kraehenbuhl J. P., Sirard J. C. |title=Mucosal interplay among commensal and pathogenic bacteria: lessons from flagellin and Toll-like receptor 5 |journal=FEBS Lett |year=2006 |volume=580 |issue=12 |pages=2976-84 |url=https://www.ncbi.nlm.nih.gov/pubmed/16650409}}.</ref>. ''DAMP'' sunt "vastitatibus sociata exempla molecularia" (''damage-associated molecular patterns''), quae sunt partes cellularum vulneratarum ''corporis poprii'' denaturatae: Quando damnum cellularum prodit, organella ex cellula liberata signum initii inflammationis fient<ref>{{cite journal |authors=Rubartelli A., Lotze M. T. |title=Inside, outside, upside down: damage-associated molecular-pattern molecules (DAMPs) and redox |journal=Curr Opin Immunol |year=2007 |volume=23 |issue=5 |pages=591-7 |url=https://www.ncbi.nlm.nih.gov/pubmed/17845865}}.</ref>.


Inter cytokina et inflammasomata cellularum immunitatis mutuo signa dantur<ref>{{cite journal |authors=Barker B. R., Taxman D. J., Ting J. P. |title=Cross-regulation between the IL-1β/IL-18 processing inflammasome and other inflammatory cytokines |journal=Curr Opin Immunol |year=2011 |volume=23 |issue=5 |pages=591-7 |url=https://www.ncbi.nlm.nih.gov/pubmed/21839623}}</ref>.
Inter cytokina et inflammasomata cellularum immunitatis mutuo signa dantur<ref>{{cite journal |authors=Barker B. R., Taxman D. J., Ting J. P. |title=Cross-regulation between the IL-1β/IL-18 processing inflammasome and other inflammatory cytokines |journal=Curr Opin Immunol |year=2011 |volume=23 |issue=5 |pages=591-7 |url=https://www.ncbi.nlm.nih.gov/pubmed/21839623}}.</ref>.


== Notae ==
== Notae ==
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* [[Apoptosis]]
* [[Apoptosis]]
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[[Categoria:Caspases]]
[[categoria:Immunitatis systema]]
[[Categoria:Immunitatis systema]]
[[categoria:inflammationes]]
[[Categoria:Inflammationes]]
[[categoria:caspases]]

Emendatio ex 11:28, 16 Septembris 2018

Cave: notitiae huius paginae nec praescriptiones nec consilia medica sunt.

Structura inflammasomatis NLRP3.

Inflammasoma (-atis, n.) est complexus proteinorum oligomerorum responsa inflammatoria[1] per varios adaptores[2] excitatus. Adaptoribus incitatum his inflammasoma enzymum caspasem 1[3] se immutare impellit ita, ut praecursor interleukini 1 beta macrophagocytis liberatus in formam activam interleukinumi 1 activi (IL-1β) et febrem generantis convertatur ideoque cataracta inflammationis biochemica continuetur.

Inflammasomata complexus, qui in textu myeloideo locati sunt ex enzymis caspasi 1 ac PYCARD et receptorio NALP et nonnumquam enzymo caspasi 5 compositi sunt. Variae formae rececptoriorum NALP complexu ligatae notae sunt.

Natura inflammasomatum

Contextus

Sub inflammationem systema immunitatis innatum machinationem defensionis contestari oportet. Post stimulationem inflammasomate primum liberatio ex cellula cytokinorum conceditur, deinde extra cellulam pyroptosis (mors cellularum programmata) fit[4].

Structura

Inflammasomata sunt complexus ex diversis proteinis compositi, ita ex enzymis caspasi 1 ac PYCARD et receptorio NALP et nonnumquam enzymo caspasi 5. Variae formae rececptoriorum NALP complexu ligatae notae sunt, quo inflammasomata NLRP1 et NLRP3[5] et NLRC4 munerum singularium nominata sunt.

Physiologia

Quando infectio prodit cellulae systematis immunitatis, ut monocyti, macrophagocyti receptoria peculiaria, receptoria exempla cognoscendorum (Anglice Pattern Recognition Receptors, PRR) enim, exprimunt: et superficie membranae et intra cellulam.

Haec PRR′ia modo duo genera stimulorum cognoscunt: PAMP vel DAMP. PAMP est abbreviatura Anglica "pathogenis sociatorum exemplorum molecularis" (pathogen-associated molecular patterns), quae sunt partes corpori alienae, per exemplum lipopolysaccharidi bacteriorum. Pluribus exemplis alienis receptoria propria ex familia receptoriorum typi Toll instar (abbreviatura internationalis: TLR) superficie cellulae sunt; Exemplum flagella bacterialia per TLR 5 superficie membranae cellularum immunitatis recognoscuntur[6]. DAMP sunt "vastitatibus sociata exempla molecularia" (damage-associated molecular patterns), quae sunt partes cellularum vulneratarum corporis poprii denaturatae: Quando damnum cellularum prodit, organella ex cellula liberata signum initii inflammationis fient[7].

Inter cytokina et inflammasomata cellularum immunitatis mutuo signa dantur[8].

Notae

  1. ↑ Martinon F., Burns K., Tschopp J. (2002). "The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta". Mol Cell 10 (2): 417-26 .
  2. ↑ Mariathasan S., Newton K., Monack D. M., Vucic D., French D. M., Lee W. P., Roose-Girma M., Erickson S., Dixit V. M. (2004). "Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf". Nature 430 (6996): 213-8 .
  3. ↑ seu interleukini 1 beta convertasis
  4. ↑ Fink S. L., Cookson B. T. (2006). "Caspase-1-dependent pore formation during pyroptosis leads to osmotic lysis of infected host macrophages". Cell Microbiol 8 (11): 1812-25 .
  5. ↑ {{cite journal |authors=Lebeaupin C., Proics E., de Bieville C. H., Rousseau D., Bonnafous S., Patouraux S., Adam G., Lavallard V. J., Rovere C., Le Thuc O., Saint-Paul M. C., Anty R., Schneck AS., Iannelli A., Gugenheim J., Tran A., Gual P., Bailly-Maitre B. |title=ER stress induces NLRP3 inflammasome activation and hepatocyte death |journal=Cell Death Dis |year=2015 |volume=6 |issue= |pages=e1879 |url=https://www.ncbi.nlm.nih.gov/pubmed/26355342}.}
  6. ↑ Rumbo M., Nempont C., Kraehenbuhl J. P., Sirard J. C. (2006). "Mucosal interplay among commensal and pathogenic bacteria: lessons from flagellin and Toll-like receptor 5". FEBS Lett 580 (12): 2976-84 .
  7. ↑ Rubartelli A., Lotze M. T. (2007). "Inside, outside, upside down: damage-associated molecular-pattern molecules (DAMPs) and redox". Curr Opin Immunol 23 (5): 591-7 .
  8. ↑ Barker B. R., Taxman D. J., Ting J. P. (2011). "Cross-regulation between the IL-1β/IL-18 processing inflammasome and other inflammatory cytokines". Curr Opin Immunol 23 (5): 591-7 .

Nexus interni

Receptum de "https://la.wikipedia.org/w/index.php?title=Inflammasoma&oldid=3369974"