PTEN inducta kinasis 1
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| PTEN inducta kinasis 1 PINK 1 | |||||
|---|---|---|---|---|---|
| Cognitores | |||||
| Alia nomina | PINK-1, BRPK, PARK6 | ||||
| Fontes externae | OMIM: 608309 | ||||
| Genetica | |||||
| Locus geni (homo) | |||||
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| Locus | 1p36.12 | ||||
| Initium | 20 633 458 | ||||
| Terminus | 20 651 511 | ||||
PTEN inducta kinasis 1 vel brevius PINK 1 est enzymum, quod mitochondria de damnis protegit. PINK 1 proteinum ligasem parkinum cum mitochondriis depolarisatis connectare iubet, ut illorum autophagocytosis (destructio) initietur[1].
Mutationes geneticae momentum morbi Parkinson habere videtur[2].
Notae[recensere | fontem recensere]
- ↑ Narendra D. P., Jin S. M., et al. (Ian 2010). "PINK1 is selectively stabilized on impaired mitochondria to activate Parkin". PLoS Biology 8 (1): e1000298
- ↑ Wu S., Lei L., et al. (Nov 2018). "Mutation of hop-1 and pink-1 attenuates vulnerability of neurotoxicity in C. elegans: the role of mitochondria-associated membrane proteins in Parkinsonism". Experimental neurology 309: 67-78
Nexus interni
Nexus externi[recensere | fontem recensere]
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