Phenothiazinum

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Phenothiazinum. In compositi organici positum mediotullio thiazinum est.

Phenothiazinum est in chemia compositum organicum formulae S(C6H4)2NH. Nonnulla phenothiazinorum medicamenta antipsychotica ad schizophreniam therapiam nota sunt[1].

Structura chemica[recensere | fontem recensere]

Structura phenothiazini est 10H-di-benzo-[b,e]-1,4-thiazinum.

Medicamenta antipsychotica[recensere | fontem recensere]

Medicamenta antipsychotica cum phenothiazino in greges tres dividuntur: composita aliphatica, piperidina, piperazina.

Grex Effectus autonomicus Exemplum Sedativum Reactio adversa
Composita aliphatica
moderate Chlorpromazinum forte moderate
Promazinum moderate moderate
Triflupromazinum forte moderate/forte
Laevomepromazinum fortissime minime
Piperidina fuerte Mesoridazinum forte lente
Thioridazinum forte lente
Piperazina lente Fluphenazinum lente/moderate forte
Perphenazinum lente/moderate forte
Prochlorperazinum
Trifluoperazinum moderate forte

Notae[recensere | fontem recensere]

  1. Jaszczyszyn A, Gasiorowski1 K, Swiatek P, Malinka W, Cieslik-Boczula K, Petrus J, Czarnik-Matusewicz B (2012). "Chemical structure of phenothiazines and their biological activity". Pharmacol Rep 64: 16-23 

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