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Emendatio ex 12:14, 15 Septembris 2018

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Inflammasoma (-atis, n.) est complexus proteinorum oligomerus inflammatoria responsa^[1] per varios adaptores^[2] excitatu. Adaptoribus incitatum inflammasoma enzymum caspasem 1^[3] se immutare impellit ita, ut praecursor interleukini 1 beta macrophagocytis liberatus in formam activam interleukinumi 1 activi (IL-1β) et febrem generantis convertatur ideoque cataracta inflammationis biochemica continuetur.

Inflammasomata complexus, qui in textu myeloideo locati sunt ex enzymis caspasi 1 ac PYCARD et receptorio NALP et nonnumquam enzymo caspasi 5 compositi sunt. Variae formae rececptoriorum NALP complexu ligatae notae sunt, quo inflammasomata NLRP1 et NLRP3^[4] et NLRC4 munerum singularium nominata sunt.

Notae

↑ Martinon F., Burns K., Tschopp J. (2002). "The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta". Mol Cell 10 (2): 417-26
↑ Mariathasan S., Newton K., Monack D. M., Vucic D., French D. M., Lee W. P., Roose-Girma M., Erickson S., Dixit V. M. (2004). "Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf". Nature 430 (6996): 213-8
↑ seu interleukini 1 beta convertasis
↑ Lebeaupin C., Proics E., de Bieville C. H., Rousseau D., Bonnafous S., Patouraux S., Adam G., Lavallard V. J., Rovere C., Le Thuc O., Saint-Paul M. C., Anty R., Schneck AS., Iannelli A., Gugenheim J., Tran A., Gual P., Bailly-Maitre B. (2015). "ER stress induces NLRP3 inflammasome activation and hepatocyte death". Cell Death Dis 6: e1879

Nexus interni

[1] Martinon F., Burns K., Tschopp J. (2002). "The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta". Mol Cell 10 (2): 417-26

[2] Mariathasan S., Newton K., Monack D. M., Vucic D., French D. M., Lee W. P., Roose-Girma M., Erickson S., Dixit V. M. (2004). "Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf". Nature 430 (6996): 213-8

[3] seu interleukini 1 beta convertasis

[4] Lebeaupin C., Proics E., de Bieville C. H., Rousseau D., Bonnafous S., Patouraux S., Adam G., Lavallard V. J., Rovere C., Le Thuc O., Saint-Paul M. C., Anty R., Schneck AS., Iannelli A., Gugenheim J., Tran A., Gual P., Bailly-Maitre B. (2015). "ER stress induces NLRP3 inflammasome activation and hepatocyte death". Cell Death Dis 6: e1879

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+[[Fasciculus:Inflammasome vector.svg|thumb|Structura inflammasomatis NLRP3.]]
 '''Inflammasoma''' {{victio|soma|atis|n}} est complexus [[proteinum|proteinorum]] [[oligomerus (chemia)| oligomerus]] [[inflammatio|inflammatoria responsa]]<ref>{{cite journal |authors=Martinon F., Burns K., Tschopp J. |title=The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta |journal=Mol Cell |year=2002 |volume=10 |issue=2 |pages=417-26 |url=https://www.ncbi.nlm.nih.gov/pubmed/12191486}}</ref> per varios ''adaptores''<ref>{{cite journal |authors=Mariathasan S., Newton K., Monack D. M., Vucic D., French D. M., Lee W. P., Roose-Girma M., Erickson S., Dixit V. M. |title=Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf |journal=Nature |year=2004 |volume=430 |issue=6996 |pages=213-8 |url=https://www.ncbi.nlm.nih.gov/pubmed/15190255}}</ref> excitatu. Adaptoribus incitatum inflammasoma [[enzymum]] [[caspasis 1|caspasem 1]]<ref>seu ''interleukini 1 beta convertasis''</ref> se immutare impellit ita, ut praecursor [[interleukinum 1 beta|interleukini 1 beta]] [[macrophagocytis]] liberatus in formam activam interleukinumi 1 activi (IL-1β) et [[febris|febrem]] generantis convertatur ideoque cataracta inflammationis biochemica continuetur.