Fasciculus:Protease mechanism summary.svg
Size of this PNG preview of this SVG file: 800 × 512 elementa imaginalia. Aliae mensurae: 320 × 205 elementa imaginalia | 640 × 410 elementa imaginalia | 1 024 × 655 elementa imaginalia | 1 280 × 819 elementa imaginalia | 2 560 × 1 638 elementa imaginalia | 1 225 × 784 elementa imaginalia.
Sua resolutio (fasciculus SVG, nominale 1 225 × 784 elementa imaginalia, magnitudo fasciculi: 529 chiliocteti)
Summarium
| Descriptio |
English: A comparison of the two mechanisms used for proteolysis. enzyme is shown in black, substrate protein in red and water in blue.The top panel shows 1-step hydrolysis where the enzyme uses an acid to polarise water which then hydrolyses the substrate. The bottom panel shows 2-step hydrolysis where a residue within the enzyme is activated to act as a nucleophile (Nu) and attack the substrate. This forms an intermediate where the enzyme is covalently linked to the N-terminal half of the substrate. In a second step, water is activated to hydrolyse this intermediate and complete catalysis. Other enzyme residues (not shown) donate and accept hydrogens and electrostatically stabilise charge build-up along the reaction mechanism. |
| Datum | |
| Fons | Thomas, Shafee, (2014). "Evolvability of a viral protease: experimental evolution of catalysis, robustness and specificity". PhD Thesis. University of Cambridge. |
| Auctor | Thomas Shafee |
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Historia fasciculi
Presso die vel tempore fasciculum videbis, sicut tunc temporis apparuit.
| Dies/Tempus | Minutio | Dimensiones | Usor | Sententia | |
|---|---|---|---|---|---|
| recentissima | 05:20, 22 Augusti 2015 | | 1 225 × 784 (529 chiliocteti) | Evolution and evolvability | User created page with UploadWizard |
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