Fasciculus:Steroidogenesis.svg

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Summarium

Descriptio
English: Enzymes, their cellular location, substrates and products in human steroidogenesis.

Shown also is the major classes of steroid hormones: progestagens, mineralocorticoids, glucocorticoids, androgens and estrogens. However, they partly overlap, e.g. mineralocorticoids and glucocorticoids. White circles indicate changes in molecular structure compared with precursors. For more information on interpretation of molecular structures, see structural formula.

HSD: Hydroxysteroid dehydrogenase

References:

  • Boron WF, Boulpaep EL (2003) Medical Physiology: A Cellular And Molecular Approach, Elsevier/Saunders, pp. page 1,300 ISBN: 1-4160-2328-3.
  • For the absence of conversion of corticosterone to cortisol: Steroid hormone biosynthesis Reference pathway (KO). KEGG: Kyoto Encyclopedia of Genes and Genomes. Kyoto University Bioinformatics Center. (1 November 2013).
There is no appreciable conversion of corticosterone to cortisol in the adrenal cortex as 21-OH steroids are poor substrates for 17-alpha hydroxylase.

Further reading:

  • Hanukoglu I (1992). "Steroidogenic enzymes: structure, function, and role in regulation of steroid hormone biosynthesis". The Journal of Steroid Biochemistry and Molecular Biology 43 (8): 779–804. DOI:10.1016/0960-0760(92)90307-5. PMID 22217824.
  • Payne AH, Hales DB (2004). "Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones". Endocrine Reviews 25 (6): 947–70. DOI:10.1210/er.2003-0030. PMID 15583024.

See also:

Polski: Enzymy biorące udział w steroidogenezie.

Uwagi: W miejscu gdzie stereochemia nie jest wyświetlana, jest taka sama jak dla Cholesterol lub w pokazanej powyżej grupie.

HSD: Dehydrogenaza hydroksysteroidu
Русский: Ферменты, участвующие в стероидогенезе человека, с указанием субстратов и продуктов, а также локализации их активности. Происходящие изменения в структуре молекул отмечены белыми кружочками. По сборнику "Медицинская физиология" (Walter F. Boron, Emile L. Boulpaep, 2003 год).
日本語: この図はヒトのステロイドホルモン生成における酵素と酵素が存在する細胞器官、基質ならびに生成物の全体図である。またこの図は（コレステロールから）プロゲステロン、鉱質コルチコイド、糖質コルチコイド、そしてアンドロゲンおよびエストロゲンに至る主要なステロイドを記述している。

図に示すとおりそれぞれ（生合成の過程で）オーバーラップするものである。 図中、白い円で囲んだところは基質と比較した分子構造の変化した箇所を示す。

なお、HSD は、ヒドロキシステロイドデヒドロゲナーゼを表す。
Datum
Fons Häggström M, Richfield D (2014). "Diagram of the pathways of human steroidogenesis". WikiJournal of Medicine 1 (1). DOI:10.15347/wjm/2014.005. ISSN 20024436.
Auctor

David Richfield (Slashme) and Mikael Häggström. Derived from previous version by Hoffmeier and Settersr.

In external use, this diagram may be cited as:

Other versions

recensere

Original. See also Evolution.
Raster (.png) version is available

Translations

  • 中文
    中文
  • 國語
    國語
  • Русский
    Русский
  • Galego
    Galego
  • العربية
    العربية
  • polski
    polski
  • German
    German
  • 日本語
    日本語
SVG genesis
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The chemistry symbols of this structural formula are drawn using the path text method.

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Evolution

A short flashback of some milestones the evolution of the picture, demonstrating the power of free licensing where anybody can contribute to making things better.

1. (March 2007) Previous image by Stannered.
4. (August 2008) Vector (.svg) version by Slashme.
2. (July 2007) Molecular structures added by Hoffmeier and Settersr.
5. (March 2009) Expansion, grouping, addition of enzyme localization, numbering of cholesterol and coloring by Mikael Häggström.
3. (November 2007) Organization and addition of enzymes by Mikael Häggström.

Potestas usoris

Creative Commons CC-Zero This file is made available under the Creative Commons CC0 1.0 Universal Public Domain Dedication.
The person who associated a work with this deed has dedicated the work to the public domain by waiving all of their rights to the work worldwide under copyright law, including all related and neighboring rights, to the extent allowed by law. You can copy, modify, distribute and perform the work, even for commercial purposes, all without asking permission.

Captions

Add a one-line explanation of what this file represents
A schematic diagram showing the chemicals, enzymes, and locations of the human steroidogenesis pathways.

Items portrayed in this file

depicts Anglica

inceptio

28 Martii 2009

media type Anglica

image/svg+xml

checksum Anglica

589c3a5c90f5b91cbf4801dfd14cb2b515a1ce31

modus determinationis: SHA-1 Anglica

data size Anglica

256 760 byte

altitudo

1 105 pixel

latitudo

1 245 pixel

Historia fasciculi

Presso die vel tempore fasciculum videbis, sicut tunc temporis apparuit.

(novissima | veterrima) Videre (recentiores 10 | ) (10 | 20 | 50 | 100 | 250 | 500).
Dies/TempusMinutioDimensionesUsorSententia
recentissima09:21, 8 Maii 2024Minutum speculum redactionis 09:21, 8 Maii 2024 factae1 245 × 1 105 (251 chiliocteti)Bjankuloski06File uploaded using svgtranslate tool (https://svgtranslate.toolforge.org/). Added translation for mk.
10:52, 28 Octobris 2022Minutum speculum redactionis 10:52, 28 Octobris 2022 factae1 245 × 1 105 (224 chiliocteti)Uxue GarcíaFile uploaded using svgtranslate tool (https://svgtranslate.toolforge.org/). Added translation for eu.
15:58, 8 Aprilis 2020Minutum speculum redactionis 15:58, 8 Aprilis 2020 factae1 245 × 1 105 (198 chiliocteti)АтаFile uploaded using svgtranslate tool (https://tools.wmflabs.org/svgtranslate/). Added translation for uk.
15:54, 8 Aprilis 2020Minutum speculum redactionis 15:54, 8 Aprilis 2020 factae1 245 × 1 105 (187 chiliocteti)АтаFile uploaded using svgtranslate tool (https://tools.wmflabs.org/svgtranslate/). Added translation for uk.
15:12, 13 Martii 2013Minutum speculum redactionis 15:12, 13 Martii 2013 factae1 245 × 1 105 (133 chiliocteti)SlashmeRemoved arrow from Corticosterone to Cortisol via CYP17A1 (see http://www.genome.jp/kegg-bin/show_pathway?ko00140+C02140 )
16:15, 9 Iulii 2012Minutum speculum redactionis 16:15, 9 Iulii 2012 factae1 245 × 1 105 (133 chiliocteti)Mikael HäggströmAddition and correction of stereochemistries at positions 11 and 17.
04:24, 9 Iulii 2012Minutum speculum redactionis 04:24, 9 Iulii 2012 factae1 245 × 1 105 (127 chiliocteti)Mikael HäggströmAdded stereochemistries, removed redundant white circle at cortisol, renamed 21-alpha hydroxylase to simply 21-hydroxylase.
05:15, 13 Decembris 2011Minutum speculum redactionis 05:15, 13 Decembris 2011 factae1 245 × 1 105 (114 chiliocteti)SlashmeAlign some text and arrows for neatness' sake.
04:56, 13 Decembris 2011Minutum speculum redactionis 04:56, 13 Decembris 2011 factae1 245 × 1 105 (114 chiliocteti)SlashmeFixed reaction scheme: corticosterone doesn't go to cortisol! Karl and Lindie, why didn't you fix it when you first found out? Tsk tsk.
12:58, 8 Maii 2010Minutum speculum redactionis 12:58, 8 Maii 2010 factae1 245 × 1 105 (114 chiliocteti)Mikael Häggströmminor move of 5-a-reductase
(novissima | veterrima) Videre (recentiores 10 | ) (10 | 20 | 50 | 100 | 250 | 500).

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