Zuclopenthixolum

E Vicipaedia
Jump to navigation Jump to search
Esculaap4.svg
Cave: notitiae huius paginae nec praescriptiones nec consilia medica sunt.


Zuclopenthixolum
Cognitores
ChemSpider 4470984
PubChem 5311507
DrugBank DB01624
Natura chemica
Zuclopenthixolum
Zuclopenthixolum
Formula chemica C22H25ClN2OS
Massa molaris 400.965 g/mol
Natura pharmacologica
Codex ATC N05AF05 (WHO)
Semivita biologica 20 horae (per os)
19 dies (i.m.)
Metabolismus iecore (hepaticus):
CYP2D6, CYP3A4
Excretio faecibus
Ad usum therapeuticum
Applicatio per os, i.m.

Zuclopenthixolum est medicamentum pharmaceuticum et antipsychoticum ad schizophreniam tractandam[1]. Substantia thioxanthenum antagonistaque receptoria dopamini D1 atque D2, adrenergica α1 et serotonini 5-HT2 obsidet. Frequenter effectus adversarii ut os siccum, ademptio conscientiae, inquies motuum sive nimium sive tarditas eorum observari possunt.

Zuclopenthixolum est Clopenthixoli cis-isomerus.

Natura zuclopenthixoli[recensere | fontem recensere]

Natura chemica[recensere | fontem recensere]

Zuclopenthixolum est cis-(Z)-2-(4-(3-(2-chloro-9H-thioxantheno-9-ilideno)-propylo)-piperazino-1-yl)-aethanolum. Massa molaris est 400.965 g/mol.

Natura pharmacologica[recensere | fontem recensere]

Codex ATC est N05AF05 (WHO).

Pharmacocinetica[recensere | fontem recensere]

Semivita biologica .[2] 20 horae est, at administratione intramusculari 19 dies. Putatur, ut in senectute concentratio substantiae in sanguine, functione CYP2D6 diminuta causa, aucta sit[3]. Excretio imprimis per faecibus (85%) fit.

Nexus interni

Notae[recensere | fontem recensere]

  1. Bryan EJ, Purcell MA, Kumar A (2017). "Zuclopenthixol dihydrochloride for schizophrenia". Cochrane Database Syst Rev 11: CD005474 
  2. IUPAC Goldbook.
  3. Tveito M., Løvsletten Smith R., et al. (Feb 2021). "Impact of age and CYP2D6 genotype on exposure of zuclopenthixol in patients using long-acting injectable versus oral formulation-an observational study including 2044 patients". European journal of clinical pharmacology 77 (2): 215-21