Proteostasis

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Responsa signorum nisus in proteostasi adumbrata.

Proteostasis (portmanteau: proteinum + homeostasis) est notio quod affirmat vias biologicas certantes integrasque intra cellulas biogenesim, flexuram, mutationem, et degradationem proteinorum intra extraque cellulam praesentes temperare.[1][2] Notio proteostasis conservatae est res maximi momenti in studio causarum morborum cum nimis malae plicationis proteinorum et degradationis consociatorum ac degradationem quae ad phenotypos facultatum amissarum efficit,[3] ac morbis degenerativis cum aggregatione consociatis.[4]

Nexus interni

Notae[recensere | fontem recensere]

  1. Powers et al. 2009.
  2. Balch et al. 2008.
  3. Mu et al. 2008.
  4. Cohen et al. 2009.

Bibliographia[recensere | fontem recensere]

  • Balch, W. E., R. I. Morimoto, A. Dillin, et J. W. Kelly. 2008. Adapting proteostasis for disease intervention. Science 319:916–919. doi:10.1126/science.1141448. PMID 18276881.
  • Cohen, E., J. F. Paulsson, P. Blinder, T. Burstyn-Cohen, D. Du, G. Estepa, A. Adame, H. M. Pham, M. Holzenberger, J. W. Kelly, E. Masliah, et A. Dillin. 2009. Reduced IGF-1 signaling delays age-associated proteotoxicity in mice. Cell 139:1157–69. doi:10.1016/j.cell.2009.11.014. PMID 20005808.
  • Mu, T.-W., D. S. T. Ong, Y.-J. Wang, W. E. Balch, J. R. Yates, L. Segatori, et J. W. Kelly. 2008. Chemical and Biological Approaches Synergize to Ameliorate Protein-Folding Diseases. Cell 134:769–781. doi:10.1016/j.cell.2008.06.037. PMID 18775310.
  • Powers, E. T., R. I. Morimoto, A. Dillin, J. W. Kelly, et W. E. Balch. 2009. Biological and Chemical Approaches to Diseases of Proteostasis Deficiency. Annual Review of Biochemistry 78:959–991. doi:10.1146/annurev.biochem.052308.114844. PMID 19298183.

Nexus externi[recensere | fontem recensere]