Hinokitiol

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Hinokitiol (β-thujaplicina)[1] est naturalis monoterpenoid invenitur in lignum arborum in familia Cupressaceae. Est tropolone inde et unum thujaplicins.[2] Hinokitiol est late usus in ore cura et curatio products debitum ad eius lato spectro antiviral,[3] antimicrobial[4] et anti-inflammatione[5] actio. Hinokitiol est Cadmiae et Ferrum ionophore, est quoque approbatum ut cibum elogium.[6]

Nomen Hinokitiol oritur ex eo, quod erat primitus separatim in Taiwanese hinoki in 1936.[7] Est etiam fere absens in laponica hinoki dum est, continentur, maximum retrahitur (de 0.04% of corde lignum massa) in Juniperus scopulorum cedrus, Hiba cedrus lignum (Thujopsis dolabrata) et in occidentis ruber cedrus (Thuja occidentalis). Potest facile extrahi ab lignum cedri, cum solvendo et ultrasonication.[8]

Hinokitiol est fabricavit se habet ad tropolone, quae deest, isopropyl substituent. Tropolones sunt nota esse quelante agentibus.

Antimicrobial actio[recensere | fontem recensere]

Hinokitiol habet a lata range of vicibus operationes, quae multa fuerint explorata, et propria in litteris. Prima, et maxime nota, est potentior antimicrobial actio contra multa bacteria et fungi, cujuscumque antibiotic resistentia.[9][10] In specie, Hinokitiol ostensum esse efficax contra Streptococcus pneumoniae, Streptococcus mutans, et Staphylococcus Aureus, quae sunt communes hominum pathogens.[11][12] Accedit, Hinokitiol ostensum inhibeo Chlamydia trachomatis et sit amet elit utile, ut topicus medicamento.[13][14]

Antiviral actio[recensere | fontem recensere]

Recent studiis ostenditur quod Hinokitiol etiam demonstrat anti-virales actio, cum dicitur in compositum cum cadmiae compositum contra plures humana virus possidet rhinovirus, coxsackievirus et mengovirus.[15] Curatio viral infectiones est in potentia ad metet massa aliquet beneficium et debet esse de dirum momentum ad global instituta, ut ad Mundi Salutem Ordo. Per deflectit viral polyprotein processus, Hinokitiol nia viral replicationem. Autem, hoc facultas est dependens, magisque divalent metal ions, quia Hinokitiol est eorum chelator.[16] Cadmiae in compositum cum Hinokitiol sustinet his facultatibus et est de quibus infra.

Alias actiones[recensere | fontem recensere]

Praeter lata-spectro antimicrobial actio, Hinokitiol etiam habet anti-inflammatione et anti-tumor operationes, ostensum in studiis numerosis cellula in vitro, et in vivo animali studiis. Hinokitiol nia key inflammatione venalicium et meatus, ut TNF-a et NF-kB. Eius potentia tractare inveterata inflammatione aut autoimmune volutpat sit explorata. Hinokitiol inventus noxia cellulis in aliquot lineas cancer cellam per inducens autophagic processibus.[17][18]

Coronavirus investigationis[recensere | fontem recensere]

Potentiale anti-virales effectus Hinokitiol oriuntur ab eius actio, ut cadmiae ionophore. Hinokitiol dat influxum cadmiae ions in cellulis, quae inhibere replicationem machina RNA virus, et postea inhibentes replicatio virus.[15] Quidam insignis RNA virus etiam humana gravedo virus et SARS.[19] Cadmiae ions potuerunt signanter inhibeo viral replicationem in cellulis, et probatum est, quod actio esset dependens, in cadmiae influxum. Hoc studio factum est, cum cadmiae ionophore pyrithione, quae functiones valde similiter ad Hinokitiol.

In cellula culturis, hinokitiol inhibeo humana rhinovirus, coxsackievirus, et mengovirus multiplicatio. Hinokitiol intercedere cum processus de viris polyproteins, sic inhibentes picornavirus replicationem. Hinokitiol nia replicatio picornaviruses per deflectit viral polyprotein adipiscing elit. In antiviral actio hinokitiol est dependens, magisque cadmiae ions.[20]

Ferrum ionophore[recensere | fontem recensere]

Hinokitiol ostensum restituere hemoglobin productio in rodents. Hinokitiol actus est, ut ferrum, ionophore, per vertentes ferrum in cellulis,[21][22] ita crescente intracellular ferrum campester. Fere 70% of ferrum in hominibus est, quae in rubrum sanguinem cellulis, in specie in hemoglobin dapibus. Ferrum est essentialis, ut fere omnibus viventibus organizati. Sed sit amet elementum plures anatomical functiones, sicut dolor onerariis ratio, deoxyribonucleic acid (DNA) synthesis, et electron turpis. Ferrum defectus potest ducere sanguinem perturbationes, ut anemia, quae potest signanter detrimentum et mentis et corporis effectus.[23]

Cadmiae synergism[recensere | fontem recensere]

Hinokitiol est cadmiae ionophore et hoc facultatem creditur inhibeo viral replicationem. In brevi, ut stannum ionophore, Hinokitiol iuvat in onerariam moleculis in cellulis per plasma membrana vel intracellular membrana, sic crescente intracellular retrahitur de quibus moleculo (e.g. Cadmiae). Ergo, per usus antiviral proprietates Cadmiae in compositum cum Hinokitiol, Cadmiae uptake potest accelerato.[24]

Cancer investigationis[recensere | fontem recensere]

In cellula culturae et animal studiis, hinokitiol ostensum inhibeo metathesis[25][26] et habet antiproliferative effectus in cancer cellulis.[27][28][29][30][31][32]

Cadmiae defectus[recensere | fontem recensere]

Cadmiae defectus fuit demonstrandum in aliquam cancer cellulis. Reversus optimum intracellular cadmiae campester potest ducere suppressio tumor incrementum. Hinokitiol est cadmiae Ionophore, tamen plus research opus est in hoc tempore ad statuam efficax concentratione de partus modos pro Hinokitiol et cadmiae.

  • "Effectus puritate alimentorum cadmiae in melanoma augmentum et experimentalis metastasis..."[33]
  • "Puritate alimentorum cadmiae defectus causat esophageal cancer progressum per inducens alia inflammatione signature..."[34]
  • "Societas inter serum cadmiae gradus et pulmonis cancer: meta-analysis observational studiis"[35]
  • ''Investigationis progressu inter cadmiae defectus, se microRNAs, et esophageal carcinoma"[36]

Products continens Hinokitiol[recensere | fontem recensere]

EWG Scoring Scale

Hinokitiol est late usus in pluribus perussi products possidet: stibio, toothpastes, oralis ramis, sunscreens et capillus augmentum. Unus ex principibus faces in venditio accumsan hinokitiol products est Hinoki Clinical. Hinoki Clinical (fundata 1956) constituta paulo post primum 'industriae extractionem hinokitiol' coepit in 1955.[37] Hinoki, currently habet super 18 diversis productum iugis cum hinokitiol ut condimentum. Aliam notam, scilicet, 'Relief Life',[38] habet gloriata super million venditionibus, cum eorum 'Dental Series' toothpaste continens hinokitiol.[39] Alia insignis pariuntur hinokitiol ex includit products Otsuka Pharmaceuticals, Kobayashi Pharmaceuticals, Taisho Pharmaceuticals, SS Pharmaceuticals. Praeterea Asia, turmas talis ut Swanson Vitamins® sunt incipiens utendo hinokitiol in perussi products in foro, ut in Civitates Foederatae Americae[40] et Australia[41] sicut anti-oxidant serum et in aliis conatur. In 2006, hinokitiol erat de genere sub Domesticis Substantiae Album in Canada, sicut non-pertinax, non-bioaccumulative et non-toxic, ut aquatilium organizati.[42]

Environmental Working Group (EWG) est an American activist coetus, quod est a page dedicavit ad ingrediens hinokitiol, significans, quod est 'humilis aleam' in areas ut "Allergies & Immunotoxicity", "Cancer" & "Developmental & Generatiua Iecur"[43], dans Hinokitiol sexaginta 1-2.

Dr. ZinX[recensere | fontem recensere]

In 2 aprilis 2020, Advance Nanotek,[44] Australian producentis spodi interposita a iuncturam patentes application cum AstiVita Limited,[45] pro an antiviral compositionem, quod includitur variis oralis cura products,[46] quae continentur hinokitiol sicut vitalis pars. Dr ZinX est notam, quod nunc est, incorporandi hoc novum inventum. Verisimile est, dimittere eius Cadmiae + Hinokitiol compositum in 2020.[47][48] Die 18 Maii 2020 Dr ZinX edita test results for a "Quantitatis suspensionis test enim aestimatio virucidal actio in medical area"[49][50] reversus a '3.25 log' reductionem (99.9% reductionem) a tersus retrahitur in 5 minutes contra COVID-19 surrogate Feline Coronavirus.[51] Cadmiae est essentialis puritate alimentorum supplementum et vestigium elementum in corpore. Globally est aestimari quod 17.3% de populatio est insufficiens Cadmiae attractio.[52][53]

Promittentes Futurum[recensere | fontem recensere]

Principio in 2000s, investigatores recognovit quod hinokitiol posset esse utilis, sicut a pharmaceutical, praesertim quia inhibentes phormidium Chlamydia trachomatis.

Pharmacopola Martini Burke et collegis ad University of Illinois ad Urbana–Planis, et ad alia instituta, inventa significant medicinae usum hinokitiol. Burke scriptor metam est vincere irregularis ferrum onerariis in animalibus. Insufficiencies plures servo potest ducere ferrum defectus in cellulis (anemia) aut opposita, Hemochromatosis[54] Usura gene-infrequenti fermentum culturarum ut subrogatur, investigatores texit a bibliotheca parva biomolecules signa ferrum onerariis et ideo cellam augmentum. Hinokitiol papaver sursum, ut in unum, quod restituit cellula munus. Praeterea opus ipsum dolor amet, constat mechanism, quam hinokitiol restituit aut minuit cell ferrum.[55] Tunc conversus eorum studium ad mammalia. Invenerunt quod cum rodentia, quod fuerat machinatum defectum "ferrum servo" sunt hinokitiol, et recuperavit ferrum uptake in ventrem. In simili studio in zebrafish, in moleculo restituit Hemoglobin productio.[56] In commentario opus Burke et al. cognomento hinokitiol in "Ferrum Homo moleculo". Hoc decet/irrisorie, quia discoverer Nozoe primum nomen potest esse translatum, ut "ferrum homo".

Significant investigationis etiam perductus de ore applications Hinokitiol, dedit augeri postulatio oralis products fundatur in Hinokitiol. Unum ex huiusmodi studium, foederata 8 alia instituta, in Iaponia, inscripsit: "Antibacterial Actio Hinokitiol Contra Utrumque Antibiotic-Repugnant et Suscipit Pathogenic Bacteria Quod Erimus in Oris Cavitatem et Superiorem Airways" venit ad conclusionem quod "hinokitiol exhibet antibacterial actio contra lato spectro pathogenic bacteria et humilis cytotoxicity erga humanum epithelial cellulis.[12]

Notae[recensere | fontem recensere]

  1. β-Thujaplicin at Sigma-Aldrich
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  3. Krenn BM, Gaudernak E, Holzer B, Lanke K, Van Kuppeveld FJ, Seipelt J (January 2009). "Antiviral activity of the zinc ionophores pyrithione and hinokitiol against picornavirus infections". Journal of Virology. 83 (1): 58–64. doi:10.1128/JVI.01543-08. PMC 2612303. PMID 18922875.
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