Enzymum angiotensinum convertens 2

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Enzymum angiotensinum convertens 2
ACE2
Cognitores
Alia nomina ACE2, ACEH
Numerus EC 3.4.17.23
(hydrolasis)
Fontes externae OMIM: 300335
Genetica
Locus geni (homo)
Chromosomate X locatum
Chromosomate X locatum
Locus Xp22.2
Initium 15 561 033
Terminus 15 602 148
Biochemia
Substratum Proangiotensinum
(angiotensinum I)

Enzymum angiotensinum convertens 2 (ACE2) (numerus EC: 3.4.17.23) est enzymum, quod proangiotensinum (seu angiotensinum I) in angiotensinum (1-7) convertit.

Enzymum praecipue in cellulis endothelialibus cordis renumque exprimitur.

Enzymum angiotensinum convertens 2 est scopus viri SARS-CoV-2 (coronaviri novi), at non medicamentorum ut inhibitorum enzymi angiotensinum convertentis.

Genetica[recensere | fontem recensere]

Genum enzymi angiotensinum convertentis, ACE2 nominatum, in hominibus in chromosomate X invenitur.

Effectus enzymi physiologicus[recensere | fontem recensere]

Enzymum angiotensinum convertens 2 proangiotensinum (angiotensinum I) in angiotensinum (1-7) convertit[1].

Angiotensini[recensere | fontem recensere]

Angiotensini est grex hormonum peptidorum. Ex angiotensinogeno praecursore hormonum (prohormone; sine effectu physiologico) in iecore ob hormon renini angiotensinum I generatur. Imprimis in pulmonibus angiotensinum I in angiotensinum II ob enzymum angiotensinum convertens (ACE) convertitur.

ACE2 porta intrandi viri SARS-CoV-2[recensere | fontem recensere]

SARS-coronaviri receptorium ad enzymum ACE2 appellunt[2].

Nexus interni

Notae[recensere | fontem recensere]

  1. Keidar S., Kaplan M., Gamliel-Lazarovich A. (Feb 2007). "ACE2 of the heart: From angiotensin I to angiotensin (1-7)". Cardiovascular Research 73 (3): 463-9 
  2. Inoue Y., Tanaka N., Tanaka Y., Inoue S., Morita K., Zhuang M., Hattori T., Sugamura K. (Aug 2007). "Clathrin-dependent entry of severe acute respiratory syndrome coronavirus into target cells expressing ACE2 with the cytoplasmic tail deleted". Journal of Virology 81 (16): 8722-9 
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