Dementia cum corpusculis Leweyanis

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Imago microscopica corpuscula Leweyania ostendens (Haematoxylino et ferro coloratum).

Dementia cum corpusculis Leweyanis est morbus neurodegenerativus et frequentia secundus ex frequentissimis cum dementiae symptomate. A prima origine proteina ex alpha-synucleino composita iuxta cerebri nervos et cellulas gliales corpusculaque Leweyania formantes aggregunt.

In morbi concursu evolvunt symptomata multiplicia, ut cerebri (dementia) vel systematis nervosi autonomici. Profecto similitudines cum morbo Parkinsoniano notabiles sunt[1].

Adhuc neque tractatio neque sanatio nota est[2].

Neuropathologia[recensere | fontem recensere]

Sub microscopio dementia cum corpusculis Leweyanis multa corpuscula inclusionis (corpuscula Leweyana enim) imprimis ex proteinis alpha-synucleino constitutis ostendit, at centesimae octoginta aegrotis etiam amyloidum beta (Aß) et proteinum tau intracerebralia sunt[3].

Degeneratio nuclei basalis MEYNERT cholinergici observatur, quare usus medicamenta inhibitores cholinesterasis commendatur[4].

Alpha-synucleinum[recensere | fontem recensere]

Crystal 128 up.png Commentatio principalis: alpha-synucleinum

Aggregatio proteini alpha-synucleini non solum in dementia cum corpusculis Leweyanis observatur, sed etiam in morbo Parkinson. Nimirum etiam mala cum morum mutatorum in somno, quae non raro cum morbo Parkinson sociata sunt, quoque in dementia hac investigari potuit[5].

Notae[recensere | fontem recensere]

  1. Outeiro T. F., Koss D. J., Erskine D., Walker L., Kurzawa-Akanbi M., Burn D., Donaghy P., Morris C., Taylor J. P., Thomas A., et al. (2019). "Dementia with Lewy bodies: an update and outlook". Molecular neurodegeneration 14 (1): 5 
  2. McKeith I. G., Boeve B. F., Dickson D. W., Halliday G., Taylor J. P., Weintraub D., Aarsland D., Galvin J., et al. (2017). "Diagnosis and management of dementia with Lewy bodies: Fourth consensus report of the DLB Consortium". Neurology 89 (1): 88-100 .
  3. Colom-Cadena M., Gelpi E., Charif S., Belbin O., Blesa R., Martí M. J., Clarimón J., Lleó A. (2013). "Confluence of α-synuclein, tau, and β-amyloid pathologies in dementia with Lewy bodies". Journal or neuropathology and experimental 72 (12): 1203-12 
  4. Barrett M. J., Cloud L. J., Shah H., Holloway K. L. (Oct 2019). "Therapeutic approaches to cholinergic deficiency in Lewy body diseases". Expert Review of neurotherapeutics 12: 1-13 
  5. Chan P. C., Lee H. H., Hong C. T., Hu C. J., Wu D. (Iun 2018). "REM Sleep Behavior Disorder (RBD) in Dementia with Lewy Bodies (DLB)". Behavioral neurology: 9421098 

Nexus interni

Nexus externi[recensere | fontem recensere]

  • NIH de morbo. (Anglice)