Carcinosarcoma

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Carcinosarcoma
Cognitores
Disciplina medica Oncologia
Rationes clinicae
Carcinosarcoma
Endometrii carcinosarcoma cum duabus partibus, carcinomatosa et sarcomatosa - In imagine linea zonae transitionalis oblique currit.

Carcinosarcoma est eodem tempore praesentia et carcinomatis (epithelio derivati) et sarcomatis (mesenchymate derivati). Carcinosarcomata tumores rari sunt. In compluribus organibus ut cute[1], glandulis salivariis[2], pulmonibus[3], oesophago[4], pancreate[5], colo[6], utero[7], ovariis[8] nonnumquam inveniri queant.

Pathologia[recensere | fontem recensere]

Examinatio histopathologica eodem tempore textus neoplasticos et cellulis epithelialibus (carcinoma) et mesenchymalibus (sarcoma) derivatos ostendit.

Carcinosarcomatum origo incerta restat, itaque adhuc hypotheses quattuor dari solent:

Mutationes geneticae ad carcinosarcomata formanda putatur, per exemplum in uteri carcinosarcomatibus mutationes proteini p53 nexus etiam ad proteinum FBXW7 et enzymum phosphoinositidi 3 kinasem indicaverunt[10].

Notae[recensere | fontem recensere]

  1. Kwak H.-B., Park J., et al. (Dec 2018). "Cutaneous Carcinosarcoma: a Clinicopathologic and Immunohistochemical Analysis of 11 Korean Cases". Journal of Korean medical sciences 34 (1): e5 
  2. Gupta A., Koochakzadeh S., et al. (Mai 2020). "Salivary Carcinosarcoma: An Extremely Rare and Highly Aggressive Malignancy". Laryngoscope 130 (5): E335-9 
  3. Diaconită G. (Dec 1975). "Bronchopulmonary carcinosarcoma". Thorax 30 (6): 682-6 
  4. Lichter I., Smith E. R., Gwynne J. F. (Nov 1968). "Carcinosarcoma of the oesophagus". Thorax 23 (6): 663-9 
  5. Li J., Wei T., et al. (Nov 2020). "Carcinosarcoma of the pancreas: comprehensive clinicopathological and molecular characterization". HPB 22 (11): 1590-5 
  6. Nakao A., Sakagami K., et al. (Apr 1998). "Carcinosarcoma of the colon: report of a case and review of the literatur". Journal of gastroenterology 33 (2): 276-9 
  7. Arend R., Doneza J. A., Wright J. D. (Sep 2011). "Uterine carcinosarcoma". Current opinion in oncology 23 (5): 531-5 
  8. Cantrell L. A., Van Le L. (Oct 2009). "Carcinosarcoma of the ovary a review". Obstetrical & gynecological survey 64 (10): 673-80 
  9. Raspollini M. R., Taddei G. L., et al. (Mar-Apr 2005). "Differential diagnosis between uterine carcinosarcoma versus carcinoma with sarcomatous metaplasia: an immunohistochemical and ultrastructural case study". Ultrastructural pathology 29 (2): 149-55 
  10. Cuevas I. C., Sahoo S. S., et al. (Dec 2019). "Fbxw7 is a driver of uterine carcinosarcoma by promoting epithelial-mesenchymal transition". Proceedings of the National Academy of Sciences of the United States of America 116 (51): 25880-90 

Nexus externi[recensere | fontem recensere]

  • Pathologyoutlines.com de carcinosarcomatibus (Anglice)
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