Biperidenum

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**Biperidenum**
Cognitores
ChemSpider	2289
PubChem	2381
DrugBank	DB00810
Natura chemica


Formula chemica	C ₂₁H ₂₉NO
Massa molaris	311.469 g/mol
Natura pharmacologica
Codex ATC	N04AA02 (WHO)
Semivita biologica	18—24 h
Metabolismus	iecore (hepaticus): hydroxylatio
Excretio	renibus
Ad usum therapeuticum
Applicatio	per os., i.m., i.v.

Biperidenum est substantia anticholinergica antagonista receptoriorum muscarinergicorum M1 et M4. Adhibetur morbi Parkinsoniani et perturbationum motuum drogis causa.

Natura pharmacologica biperideni

Biperidenum substantia anticholinergica antagonista receptoriorum muscarinergicorum M1 et M4 est^[1]. Effectus clinici 6-8 horas remanent.

Maxima hominis dosis diurnalis 16 mg valet. Antidotum physostigminum, parasympathomimeticum indirectum (inhibitione acetylcholini esterasis), est.

Semivita biologica $t_{\frac {1}{2}}$ .^[2] 18-24 h est. Excretio maiore in parte per renes est.

↑ Palombo P., Engi S. A., et al. (Feb 2021). "Effects of biperiden (cholinergic muscarinic m1/m4 receptor antagonist) on ethanol conditioned place preference in mice". Neuroscience letters 745: 135551 .
↑ http://goldbook.iupac.org/B00658.html
↑ Richardson C., Kelly D. L., Conley R. R. (Aug 2001). "Biperiden for excessive sweating from clozapine". American journal of psychiatry 158 (8): 1329-30 .
↑ Caflisch C., Figner B., Eich D. (Feb 2003). "Biperiden for excessive sweating from methadone". American journal of psychiatry 160 (2): 386-7 .