Biperidenum
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Cave: notitiae huius paginae nec praescriptiones nec consilia medica sunt. |
| Cognitores | |
|---|---|
| ChemSpider | 2289 |
| PubChem | 2381 |
| DrugBank | DB00810 |
| Natura chemica | |
| |
| |
| Formula chemica | C 21H 29NO |
| Massa molaris | 311.469 g/mol |
| Natura pharmacologica | |
| Codex ATC | N04AA02 (WHO) |
| Semivita biologica | 18—24 h |
| Metabolismus | iecore (hepaticus): hydroxylatio |
| Excretio | renibus |
| Ad usum therapeuticum | |
| Applicatio | per os., i.m., i.v. |
Biperidenum est substantia anticholinergica antagonista receptoriorum muscarinergicorum M1 et M4. Adhibetur morbi Parkinsoniani et perturbationum motuum drogis causa.
Biperidenum in ordinis mundi sanitarii indicem exemplarem medicamentorum essentialium receptum est.
Natura pharmacologica biperideni[recensere | fontem recensere]
Pharmacodynamica[recensere | fontem recensere]
Biperidenum substantia anticholinergica antagonista receptoriorum muscarinergicorum M1 et M4 est[1]. Effectus clinici 6-8 horas remanent.
Maxima hominis dosis diurnalis 16 mg valet. Antidotum physostigminum, parasympathomimeticum indirectum (inhibitione acetylcholini esterasis), est.
Pharmacocinetica[recensere | fontem recensere]
Semivita biologica .[2] 18-24 h est. Excretio maiore in parte per renes est.
Usus medicus[recensere | fontem recensere]
- Morbus Parkinsonianus
- Perturbationes motuum drogis (ut antipsychoticis) causa
- Hypersalivatio (sialorrhoea) consumptione clozapini[3], methadoni[4].
Notae[recensere | fontem recensere]
- ↑ Palombo P., Engi S. A., et al. (Feb 2021). "Effects of biperiden (cholinergic muscarinic m1/m4 receptor antagonist) on ethanol conditioned place preference in mice". Neuroscience letters 745: 135551.
- ↑ http://goldbook.iupac.org/B00658.html
- ↑ Richardson C., Kelly D. L., Conley R. R. (Aug 2001). "Biperiden for excessive sweating from clozapine". American journal of psychiatry 158 (8): 1329-30.
- ↑ Caflisch C., Figner B., Eich D. (Feb 2003). "Biperiden for excessive sweating from methadone". American journal of psychiatry 160 (2): 386-7.
Nexus interni
Nexus externi[recensere | fontem recensere]
- drugs.com cum monographia biperideni (Anglice)